Postoperative cognitive dysfunction (POCD) has been attributed to long-acting sedatives. We hypothesized that diazepam and its active metabolites could be detected in blood after surgery and correlated with POCD, 1 week after surgery in elderly patients.

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Postoperative cognitive dysfunction 1. Introduction. Advances in surgical techniques and in anaesthetic care have resulted in a substantial reduction of 2. Definition. It has long been observed that anaesthesia and surgery can be associated with changes in cognition of 3. Incidence. The Abstract Postoperative delirium and postoperative cognitive dysfunction both occur in a substantial number of older surgical Postoperative delirium and postoperative cognitive dysfunction share risk factors and may co-occur, although their Post-operative cognitive dysfunction (POCD) is a disorder of thought processes, influencing isolated domains of cognition such as verbal or visual memory, language comprehension, visuospatial abstraction, attention, or concentration in absence of a better disease which explains the symptoms.

Postoperative cognitive dysfunction

Emerging research suggests that postoperative cognitive dysfunction (POCD) is common after lung transplantation, occurring in more than half of recipients. 6-8 POCD may have important clinical implications, as poorer neurocognitive function has been associated with worse quality of life, greater risk of medication nonadherence 9, 10 and poorer clinical outcomes in other patient populations. 11 Number of patients with postoperative cognitive dysfunction (POCD) (POCD is a composite outcome measure) [ Time Frame: At 3 months after the surgery ] Incidence of POCD in patients will be determined by a set of cognitive tests. Postoperative cognitive dysfunction (POCD) is a common central nervous system complication after anesthesia and surgery, characterized by a decline in cognitive performance [1, 2]. POCD is commonly observed in elderly patients, who often develop impaired concentration, memory, and learning after surgery [ 2 ].

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cognitive dysfunction [28-30] (Table 1). The key pathogenic mechanisms of postoperative cognitive dysfunction are a) Neurotoxicity b) Defect in neurotransmission c) Neuroinflammation a) Neurotoxicity There is mounting evidence revealing anaesthetics to be powerful modulators of neuronal development and function [31].

Postoperative cognitive dysfunction (POCD) has been attributed to long-acting sedatives. We hypothesized that diazepam and its active metabolites could be detected in blood after surgery and correlated with POCD, 1 week after surgery in elderly patients.

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Postoperative cognitive dysfunction (POCD), a long-lasting cognitive decline after surgery, is currently a major clinical problem with no clear pathophysiological mechanism or effective therapy. Accumulating evidence suggests that neuroinflammation plays a critical role in POCD. Postoperative cognitive dysfunction (POCD) refers to the complications of the central nervous system before and after surgery in patients without mental disorders. Many studies have shown that surgical anesthesia may cause POCD, especially in elderly patients. Postoperative cognitive dysfunction (POCD) is a subtle disorder of thought processes, which may influence iso - lated domains of cognition and has a significant impact on patient health.

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Postoperative cognitive dysfunction due to inhaled anesthesia is not well established. The objective of the present study was to compare the incidence of postoperative cognitive dysfunction in patients undergoing major cardiac surgeries Whether postoperative cognitive dysfunction is a permanent disorder of irreversible brain damage associated with structural cerebral changes and neuron loss still needs to be confirmed. The possibility of postoperative cognitive dysfunction after minor surgery in elderly patients and major surgery in younger patients also warrants investigation. Postoperative cognitive dysfunction (POCD), a long-lasting cognitive decline after surgery, is currently a major clinical problem with no clear pathophysiological mechanism or effective therapy.
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Postoperative cognitive dysfunction (POCD) is a syndrome of cognitive dysfunction following anesthesia and surgery, which likely has myriad causes. As an increasing number of elderly patients undergo surgery and anesthesia each year,

Kognitiva postoperativa komplikationer. av P Jildenstål · Citerat av 3 — Influence of depth of anaesthesia on postoperative cognitive dysfunction (POCD) and inflammatory marker av. Pether Jildenstål. Akademisk avhandling.

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Postoperative cognitive dysfunction refers to a persistent cognitive dysfunction that occurs subsequent to surgery and anesthesia that is beyond postoperative delirium, a transient state of cognitive change. Until recently, the majority of research on postoperative cognitive dysfunction has focused on cardiac surgery.

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